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Wednesday, 5:26 AM

July 2, 2025

Good morning news friend! Uncover the moments driving today’s world and paving the way for tomorrow. 📰🌟

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Senate Vote Advances Trump’s Big Beautiful Bill

The Senate passed Trump’s $3.3 trillion tax-cut and spending bill 51-50, with Vice President Vance breaking the tie.

The bill extends 2017 tax cuts, adds breaks for tips and overtime, increases military and immigration spending, and cuts $930 billion from Medicaid and food aid. It raises the federal debt ceiling by $5 trillion, increasing national debt by $800 billion more than the House version.

Alaska’s Murkowski secured $50 billion for rural hospitals and extra food aid. The House faces opposition over Medicaid cuts and tax relief. Medicaid tightening may add 12 million uninsured. Republicans dispute debt impact estimates.

Sources: Reuters, AP News, Bloomberg, NYTimes, Bloomberg.

Trump Announces 60-Day Gaza Ceasefire

Israel agreed to a U.S.-brokered 60-day ceasefire in Gaza, with Qatar and Egypt mediating the proposal to Hamas. President Trump urged Hamas to accept, warning of worsening conditions otherwise.

About 50 hostages remain in Gaza; Hamas demands Israeli withdrawal before release, while Israel insists on Hamas disarming. Israeli forces prepare for possible ground operations as civilians evacuate Gaza City’s north.

Humanitarian conditions deteriorate, with Shifa Hospital suspending dialysis due to fuel shortages. Diplomatic talks on ceasefire, hostages, and Iran are scheduled next week between Netanyahu and Trump amid regional escalations.

Sources: AP News, Bloomberg, AXIOS, Reuters, WallStreetJournal.

Big Banks Boost Dividends

JPMorgan Chase, Bank of America, Wells Fargo, Goldman Sachs, Citigroup, and Morgan Stanley raised dividends and announced buybacks after passing the Federal Reserve’s 2025 stress tests.

JPMorgan launched a $50 billion buyback, Morgan Stanley approved $20 billion. Banks held an average common equity Tier 1 capital ratio of 11.6%, above the 4.5% minimum.

The Fed plans to revise stress tests by averaging results over two years and easing capital requirements for low-risk assets based on global size. Federal Reserve Vice Chair Michelle Bowman said large banks are well capitalized to withstand a severe recession.

Sources: Reuters, Bloomberg, PYMNTS, FinancialTimes.

Job Market Surprise

U.S. job openings rose by 374,000 in May to 7.77 million, led by leisure and hospitality (+314,000) and finance (+91,000). Hiring fell by 112,000 to 5.503 million, with declines in healthcare, manufacturing, and professional services, while accommodation and food services surged.

Layoffs dropped by 188,000 to 1.601 million, but quits rose by 78,000 to 3.293 million. Unemployment claims hit a 3.5-year high amid job placement challenges.

The ISM manufacturing PMI stayed below growth territory at 49.0. Economists expect the Fed to hold rates steady until September amid mixed labor signals.

Sources: Reuters, Forbes, ABCNews, Bloomberg.

Sugar and Enzymes in Alzheimer’s Fight

Researchers uncovered two sugar-related mechanisms driving Alzheimer’s progression. Neurons accumulate excess glycogen that binds toxic tau proteins, increasing oxidative stress and damage.

Activating glycogen phosphorylase (GlyP) redirects glycogen breakdown to protective pathways, reducing tau damage and extending fruit fly lifespan. Dietary restriction and the drug 8-Br-cAMP boost GlyP activity, enhancing brain protection. Separately, the enzyme ST6Gal-I elevates levels of BACE1, which produces harmful amyloid-β42 plaques.

Knocking out ST6Gal-I in rats lowers BACE1, reduces plaques, and improves cognition. Reducing ST6Gal-I increases BACE1 degradation, decreasing neuron death. These findings suggest targeting sugar metabolism and glycosylation enzymes could yield new Alzheimer’s therapies involving diet, drugs, or gene editing to slow cognitive decline.

Sources: SciTechDaily, NSN, Drugtargetreview.

Synthetic Human Genomes

The Synthetic Human Genome project aims to digitally design and create one full human chromosome (2% of the genome) within 5 to 10 years, funded with £10 million.

It could enable designer cell therapies and virus-resistant tissues, though complete synthetic human genomes remain decades away. AI is accelerating synthetic biology by automating DNA reading, editing, and design, reducing development time.

However, AI’s "black box" nature raises biosecurity risks, potential misuse, and oversight challenges. Current regulatory frameworks lag behind technological advances.

Experts call for stronger international cooperation, ethical governance, and "human-in-the-loop" controls to manage AI-driven biological designs and balance innovation with safety and social concerns.

Sources: Sciencealert, Thedebrief, Nature, Msn.

“Forget a man's stated principles and find his thumbscrew—the primitive idol of fame, greed, or pleasure that truly governs his will. Once you know this mainspring, you own the key to his volition; a single, well-aimed temptation is enough to give checkmate to his freedom.”

Did you know we also write in-depth deep dives? They are long, packed with insights, and have received rave reviews. If you’re up for a detailed, action-packed read, check them out:

• America’s Housing Paradox - An Analysis of the US Housing Market

• The Stablecoin Trilemma - Bridging Digital Finance, Monetary Policy, and Systemic Risk

• Deconstructing the $66 Billion Citiadel Enigma

Baked with love,

Anna Eisenberg ❤️