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Anna's Daybreak News

_{Just facts, you think for yourself}

Wednesday, 5:03 AM

October 29, 2025

Good morning news friend! Discover today’s defining stories and the future they set in motion. 📰🌟

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Trump’s Asia Push

President Trump’s Asia trip includes trade talks with South Korea, aiming to resolve deadlock over a $350 billion investment deal.

In Tokyo, Japan pledged up to $400 billion in investments in energy, AI, and critical minerals, following a $550 billion U.S. pledge.

Trump emphasized reducing trade barriers and U.S. economic security at the APEC summit. A meeting with China’s Xi Jinping may address lowering U.S. tariffs on fentanyl-related goods and AI technology, after partial easing of tariffs on rare earth exports boosted markets.

North Korea's recent nuclear-capable missile tests raise security concerns. Markets rose during the trip.

Sources: Bloomberg, Bloomberg, Bloomberg, Bloomberg, Reuters, AP News. 

U.S. Military Strikes Drug Trafficking Vessels

The Trump administration launched its largest military strike against drug traffickers in the eastern Pacific, destroying four boats and killing 14 suspects.

Since September, U.S. forces have conducted at least 13 strikes in the Caribbean and Pacific, killing about 57 traffickers from Venezuela, Colombia, and Ecuador. The Pentagon deployed the Gerald Ford carrier strike group, adding roughly 10,000 troops and advanced military assets to Latin America.

Congressional leaders have limited insight into operations, with information restricted by nondisclosure orders. Mexico criticized the strikes, Venezuela condemned the U.S. buildup, and U.S.-Colombia relations worsened after sanctions and accusations against President Petro.

Legal experts question the military’s role in these lethal counter-narcotics strikes.

Sources: Bloomberg, AP News, Reuters, Reuters.

Nvidia’s AI Market Value Near $5 Trillion

Nvidia new AI chips, Blackwell and Rubin, are expected to generate $500 billion in revenue through 2026. Its market capitalization approached $5 trillion after a 50% stock surge in 2025.

Nvidia is building seven U.S. Department of Energy supercomputers, including one with 100,000 Blackwell chips for nuclear weapons development, partnering with Oracle. Uber plans to deploy 100,000 Nvidia-powered robotaxis by 2027, following a data-sharing deal to improve AI models.

Nvidia leads global AI adoption amid U.S.-China trade tensions. CEO Jensen Huang praised President Trump’s policies during a Washington event, highlighting Nvidia’s expanding AI influence.

Sources: Bloomberg, Reuters, Bloomberg.

Did you know we also write in-depth deep dives? They are long, packed with insights, and have received rave reviews. If you’re up for a detailed, action-packed read, check them out:

• Social Security Squeeze

• The Widowhood Penalty

• The Asset Protection Blueprint

• The Retirement Tax Bomb

• Inflammation Crisis

• The Gut Brain Axis

• AI Proof Professionals

ICE Workings

The Trump administration is replacing nearly half of ICE field office directors, affecting up to 12 of 25 offices, to increase immigration arrests. New leaders, mainly from Border Patrol, will shift tactics from targeted arrests to broad raids.

The administration targets 3,000 daily arrests, per Stephen Miller. In Chicago, a federal judge ordered daily court appearances and use of body cameras by Border Patrol commander Gregory Bovino after citing excessive force, including firing tear gas at peaceful protesters and children.

Homeland Security Secretary Kristi Noem advocates focusing on arresting undocumented immigrants with criminal records, while ICE and Border Patrol leaders support broader arrests. Legal challenges and court blocks complicate enforcement efforts.

Sources: AP News, AP News, AXIOS.

25-Year Crohn’s Disease Mystery Solved

Researchers solved how NOD2 gene mutations cause Crohn’s disease by combining AI and molecular biology. They identified 53 genes distinguishing inflammatory from healing macrophages, focusing on girdin, a protein binding NOD2 to regulate gut inflammation and tissue repair.

Common Crohn’s mutations remove NOD2’s girdin-binding region, disrupting this control, leading to persistent inflammation and gut damage. Mice lacking girdin developed gut inflammation, microbiome disruptions, and fatal sepsis. Activating NOD2 protected healthy mice but not girdin-deficient ones, confirming the bond’s importance.

This discovery explains the 25-year-old genetic puzzle and suggests new treatments aimed at restoring the NOD2-girdin interaction to rebalance gut immunity, advancing Crohn’s therapy beyond broad immune suppression.

Sources: SciTechDaily, Thebrighterside, Ucsd.

Off-The-Shelf Cancer Treatment

MIT and Harvard researchers engineered donor-derived CAR-NK cells with modified surface proteins to evade immune rejection, enabling off-the-shelf cancer treatments.

Current CAR-NK therapies use patient-derived cells requiring weeks to prepare. These engineered cells combine immune evasion with enhanced cancer-killing ability in one genetic construct.

In mice, the new CAR-NK cells persisted at least three weeks, unlike standard ones that were quickly rejected. They also reduced cytokine release syndrome risk. This approach may improve CAR-T therapies, which are effective only for some patients.

Human clinical trials are planned to test the potential of ready-made CAR-NK cells as practical cancer immunotherapies.

Sources: Sciencealert.

“A fella who is constantly fussing about the dignity of his office is just showing the world that the hat is too big for his head. It is far better to be valued for your own horse sense than for the high horse you happen to be sitting on.”

Baked with love,

Anna Eisenberg ❤️