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Ukraine Security Guarantees, US Housing Surges and Psoriasis Inflammation
Anna Eisenberg
December 29, 2025
In partnership with
Anna's Daybreak News
Just facts, you think for yourself
Tuesday, 5:21 AM
December 30, 2025
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Ukraine Security Guarantees
Ukraine seeks a 30 to 50-year US security guarantee to deter Russia; Trump offered 15 years post-war. Talks between Trump and Zelensky at Mar-a-Lago focused on a 20-point peace plan, with security guarantees requiring congressional approval and European support.
Key disputes include control over Donetsk, where Ukraine refuses Russian demands to withdraw troops, and the Zaporizhzhia Nuclear Power Plant’s status under Russian occupation. Russia rejects ceasefire proposals and local referendums. Putin accused Ukraine of drone attacks, which Kyiv denies.
Ukraine plans a security advisor summit in early 2026; a follow-up Trump meeting is scheduled. Russia holds 20% of Ukrainian territory.
Sources: WallStreetJournal, AP News, Reuters, Bloomberg.
Is a 15-year security guarantee from the U.S. sufficient to deter future Russian aggression?Click to see live results and comment! |
US Housing Surges
Pending US home sales rose 3.3% in November 2025, the highest since February 2023, with all regions gaining and a 2.6% year-over-year increase. Lower mortgage rates (30-year fixed at 6.18%) and rising wages improved affordability.
The Federal Reserve’s overnight repo lending hit $25.95 billion, the third-highest since 2021, at 3.75%, after removing a $500 billion daily cap to enhance flexibility. Cash in the Fed’s reverse repo facility dropped to $10.55 billion from $20.34 billion.
The Fed paused balance sheet reduction and resumed buying short-term bonds to manage liquidity and interest rates. These moves suggest steady economic momentum and close Fed oversight of market stability as 2025 ends.
With mortgage rates near their lowest since last fall, do you expect home prices to stabilize or continue rising?Click to see live results and comment! |
Everyone told you the tax cuts were expiring in 2025. They were wrong.
While the news cycle was distracted, the "One Big Beautiful Bill Act" (OBBBA) quietly passed. It didn't just keep the status quo—it created a specific, 4-year window to build dynastic wealth.
We call this the 2026 Wealth Ladder.
Most people are just reacting to April 15th. The elites are already pulling five specific levers created by this new bill:
The $15M Weapon: The estate tax exemption didn’t sunset. It’s now $15 million and permanent. If you aren't freezing assets now, you’re volunteering to pay 40% later.
The SALT Unlock: Live in a high-tax state like NY or CA? The deduction cap just quadrupled to $40,000.
The QBI Lock-In: That 20% deduction for business owners is no longer temporary. It’s a permanent structural advantage.
But here is the catch: While some laws are permanent, the "Goldilocks Zone" for stacking these benefits ends in 2029.
You have 48 months to optimize. Don't waste them.
Meta Bets on Agentic AI
Meta acquired Singapore-based AI startup Manus for over $2 billion, its third-largest deal after WhatsApp and Scale AI.
Founded in 2022, Manus specializes in autonomous AI agents used for research, coding, and automation, reaching $100 million ARR by late 2025 with millions of users. Manus’ technology, leveraging models from Anthropic and Alibaba, reportedly outperforms OpenAI’s DeepResearch.
Prior to acquisition, Manus was valued at $2 billion, with investors including Benchmark, Tencent, and ZhenFund. Post-acquisition, Manus will operate independently, with co-founder Xiao Hong joining Meta as VP.
Meta plans to integrate Manus’ AI into Instagram and WhatsApp, aiming to expand AI capabilities amid competition from Google, Microsoft, and OpenAI.
Sources: Bloomberg, Reuters, WallStreetJournal, Technode
Meta’s heavy investment in AI agents signals the next phase of social media. Is this a positive or concerning shift?Click to see live results and comment! |
You know the old playbook. Put 60% in stocks, 40% in bonds, and wait 30 years to get rich.
That playbook is burning.
Between 2020 and 2022, the "safe" 60/40 portfolio lost 16%. Bonds, which were supposed to be your airbag, actually crashed harder than stocks in some quarters.
But here is the stat that actually scares me: The stock market is running out of stocks. In 1996, there were over 7,000 public companies you could buy. Today? Fewer than 4,000. The "store" is half empty.
Meanwhile, the "Smart Money" (think Yale and the guys running $100B endowments) left the building years ago. They aren't buying the S&P 500. They are buying private equity, private credit, and assets that don't care what the Fed does on a Tuesday.
They’ve been capturing a "illiquidity premium" that has beaten the public market by 500 basis points annually for a quarter-century.
We just dropped a massive Deep Dive on exactly how this "Parallel Financial System" works. It covers:
Why the "Volatility Tax" is eating your compounding.
The "De-equitization" trend (where did all the companies go?).
How to build a "Fortress Portfolio" that mimics the top 1%.
Stop playing a game that broke in 2022.
First U.S. Drone Strike Inside Venezuela
The Trump administration conducted its first U.S. drone strike inside Venezuela, targeting a port used by the Tren de Aragua gang to store and ship narcotics. The strike destroyed boats and the dock without casualties.
The operation supports efforts to pressure Venezuelan President Nicolás Maduro, who is linked to drug trafficking. The CIA, with expanded covert authority, and special forces provided intelligence for the strike, possibly using MQ-9 Reaper drones armed with Hellfires based in Puerto Rico.
The U.S. has targeted over 30 drug boats and imposed oil tanker blockades. Venezuela condemned the attack as "imperial madness." The U.S. offers $50 million for information leading to Maduro’s capture.
Sources: NYTimes, Israelhayom, Reuters.
Do you believe the U.S. drone strike inside Venezuela was justified as a preventative anti-drug measure?Click to see live results and comment! |
Colorectal Cancer Breakthrough
Colorectal cancer tumors contain two distinct regulatory T cell (Treg) types affecting survival differently. IL-10-positive Tregs limit tumor growth by suppressing harmful Th17 cells, improving patient outcomes.
IL-10-negative Tregs inhibit cancer-fighting CD8+ T cells, leading to worse outcomes. The harmful IL-10-negative Tregs express high CCR8 levels, making CCR8 a target for antibody therapies currently in clinical trials to selectively remove these cells. Similar Treg subtypes appear in skin, mouth, throat, and stomach cancers, suggesting broader therapy applications.
Liver metastases show more harmful IL-10-negative Tregs, indicating location-specific treatments. Most colorectal cancers resist existing immunotherapies, so targeting Tregs could offer new treatment options and improve survival.
Sources: SciTechDaily.
Should cancer treatments focus more on selectively targeting harmful immune cells rather than broadly suppressing all Tregs?Click to see live results and comment! |
Psoriasis Inflammation
Researchers discovered that immune cells shed their sugar coating, the glycocalyx, to migrate from blood into skin during inflammation, contradicting prior beliefs that only blood vessel cells changed sugar layers.
This shedding facilitates immune cell tissue entry but can lead to excessive cell buildup in psoriasis. The finding explains a key mechanism in psoriasis inflammation and could influence drug development targeting immune cell movement to treat infections and inflammatory diseases.
The study was led by Dr. Megan Priestley and colleagues and funded by The Wellcome Trust and the Royal Society.
Sources: SciTechDaily
The finding that immune cells actively shed their sugar coating to move into tissues challenges prior beliefs. Do you think this discovery will significantly change how we understand inflammation?Click to see live results and comment! |
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Anna Eisenberg ❤️
What did you think of today's edition?Click to see live results and comment! |